This situation comedy series follows the lives of the Mitchell family, Henry, Alice, and their only child Dennis, an energetic, trouble-prone, mischievous, but well-meaning boy, who often tangles with his peace-and-quiet-loving neighbor George Wilson, a retired salesman, or, later, with George's brother John, a writer. Dennis is basically a good, well-intentioned boy who always tries to help people, but who winds up making situations worse – often at Mr. Wilson's expense.