An ensemble comedy that follows the chaotic life of George Lopez, a recently divorced working class Mexican-American turned successful entrepreneur caught between two cultures. He struggles to balance the parenting demands of his All-American Anglo ex-wife Mackenzie and the cultural expectations of his overbearing Mexican-American mother Alma.
As George attempts to relate to his 11-year-old son Harper, his life is further complicated by his fun-loving but freeloading uncle Tio and cousin Junior. As a wealthy businessman, George also gives back by teaching history to a multi-cultural classroom at a night school in downtown Los Angeles, where he's supervised by tough and sexy Assistant Principal Concepcion. Ultimately, Saint George is a celebration of a multi-generational family that humorously wrestles with cultural differences.