Cousins Naomi, Drew and Chitoka nearly weigh a combined 2,000 pounds. With the help of Dr. Charles Procter Jr., the desperate cousins attempt to overcome anxieties and live healthier lives, and this series follows their progress. It begins with Naomi's mom, Beverly, undergoing weight-loss surgery, which she hopes will inspire her daughter, niece and nephew to follow her footsteps. Despite seeing the complications involved in her mom's recovery, Naomi is motivated by her dream to start a family. Drew, meanwhile, needs to realize how addictive his eating habits have become, and Chitoka – bed-bound for more than three years – must literally take steps forward before qualifying for surgery.