Amber dreams of escaping her small town existence and persuades her friends to accompany her to find an apartment in the big city. When their transportation breaks down, she and her friends gratefully accept a ride in the back of a semi. But when the driver refuses to stop and they discover the cargo is hundreds of cartons of blood, they panic. Their panic turns to terror when the truck disgorges them into a dark, abandoned warehouse where blood-thirsty creatures learn to hunt human prey, which, the friends realize, is what they now are the human prey fighting to save their lives the realize they must work together but will they survive.