The protagonist of ''Hyderabad Blues'' is Varun, played by the director, Nagesh Kukunoor. The movie revolves around his visit to his home after 12 years in the USA and his resulting culture shock. The movie is a romantic comedy, following Varun's attempts to romance an Indian doctor and balance the local customs of arranged marriage with the Western tradition of dating. The dialogue is primarily in English and Telugu language, with some Hindi language spoken as well.