Having been diagnosed as terminal disease, Henry Poole purchases a Tract housing in his hometown, a working class suburb of Los Angeles, and awaits the inevitable, fortified with whiskey and frozen pizza. His peaceful solitude and self-imposed exile are disrupted by his meddling neighbor Esperanza Martinez, who insists she sees the face of Christ embedded in the stucco wall of his home and is convinced the image has miraculous powers when it begins to exude drops of blood. Before long, she is leading pilgrimages to his backyard and inviting Father Salazar from the local parish to bless the supposedly sacrosanct blemish. To Henry the image is a water stain.