As well as conducting extraordinary interviews with some of the world's most famous people — Bono, Bill Clinton, John Travolta, Mel Brooks, Cate Blanchett, Al Gore, Steven Spielberg — host Andrew Denton also talks with those not normally found on the talk show circuit: con men, Nobel Peace Prize winners, nurses, truckies, schizophrenics, mountaineers, homeless people and murderers. Using humour and original lines of questioning, Andrew manages to open up his guests in ways that surprise even them.