Yamato Kazakiri, a zoologist, discovers Zyuland, inhabited by anthropomorphic Zyumans. Concurrently, Dethgaliens arrive for their 100th Blood Game on Earth. Four Zyumans—Sela, Leo, Tusk, and Amu—join forces with Yamato to defend both worlds. Possessing Champion's Proofs, they become Zyuohgers to battle Dethgaliens. Trapped in the human world due to insufficient Proofs, they aid Yamato while searching for the sixth. Amidst fights and challenges, they liberate Misao, who becomes Zyuoh The World, uniting to confront Dethgaliens.