"Zerophilia" is a fictional condition that affects an unknown number of people with an extra XY sex-determination system. Following their first full sexual experience, zerophiliacs begin to change sex after experiencing an orgasm. Luke (Taylor Handley), a young man somewhat insecure about his masculinity, begins to exhibit zerophilia following an encounter with a woman (Kelly Le Brock). He meets Michelle (Rebecca Mozo) and experiences partial transformations when they go out together.