Ethan Mascarenhas (Hrithik Roshan) is a former magician who is a quadriplegic. He becomes the Radio Jockey of an FM Station called Radio Zindagi. His show spreads magic, hope, and laughter through his irrepressible wit and humor to every listener and caller, making it difficult to imagine that this is a man who has been immobilized with a spinal injury for the last fourteen years of his life. Sofia D'Souza (Aishwarya Rai) is his nurse who has been accompanying him for the past twelve years.