Marcus (Kristopher Shepard) is a paramedic who one night on the job becomes emotionally attached to a well-regarded woman named Emma Carillo (Rachel Emmers), a dying patient with five stab wounds. He attempts to help save her life, but she dies at the Mercy Hospital, as a near-death patient, Caroline Kuntz (JJ Neward), awakes, kills two people and leaves. Marcus finds his life spiraling down when he witnesses his wife, Carla (Ava Gaudet), sleep with a stranger. Along with finding out Emma had died before he aided her revival, Marcus is also suspended from work for the medical mistreatment and death of a prostitution, Elizabeth Markham, as Private detective Carruthers (Ving Rhames) is assigned to investigate the case.