Former co-stars and real-life friends Shannen Doherty and Holly Marie Combs travel on an adventure-fueled road trip through the southeastern United States, participating in activities for which viewers voted online, affecting the production team in real time. From tomato fights in Kentucky and moonshine-making in Tennessee, to ghost tours in Georgia and dirt track races in Alabama, Shannen and Holly are game for anything on their six-state tour. Along the way, their mutual love of animals takes them to a horse sanctuary near Lexington where they fall in love with a young foal and to the Georgia Sea Turtle Center where they help the staff tag and release a feisty alligator.