The tight relationship of the inseparable Ramirez siblings went down the drain when they lost their parents in a fire. The older Ramirez sibling blames her younger sister for their ill fate and leaves her alone in the orphanage they were both in. Years later, Ana Dimasalang (Julia Montes) is a paramedic who rescues Gael (Paulo Avelino) in an accident. As Ana and Gael's relationship starts to blossom, Samantha (Shaina Magdayao) suddenly comes into their lives to ruin their budding romance. Samantha wins Gael back after she ordered Ana's death. Little did she know, Ana survives the assassination and vows to exact revenge to the people who destroyed her life.