This is the story of Catalina, the indigenous woman who gave away her soul, her heart and her life to a conqueror. "The Queen and the Conqueror" rebuilds one of the first love stories that took place in America, between an indigenous woman and a Spaniard. After establishing the city of Cartagena, Pedro de Heredia, motivated by the need to save his brother, betrays Catalina. Heartbroken, she escapes, only to come back 18 years later, as a grown woman. In her soul, her only mission is: revenge. To end Pedro de Heredia's life, the same way that he, after making her fall for him, ended hers.