Set in the Ming Dynasty under the rule of Emperor Zhu Qi Zhen, Tan Yun Xian comes from a long line of medicine practitioners, her family having served as court physicians for several generations. However, the practice for female physicians came to a halt when many were framed for abusing the form. Yet, Yun Xian is determined to learn medicine and so she does in secrecy, except things become difficult when her paths cross with the Emperor himself.